Cart
sales@molnova.com
Atiprimod dihydrochloride
CAS No. 130065-61-1
Atiprimod dihydrochloride( SKF 106615 | Azaspirane )
Catalog No. M11208 CAS No. 130065-61-1
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1233 | Get Quote |
|
| 50MG | 2502 | Get Quote |
|
| 100MG | 3330 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAtiprimod dihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionAtiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
-
DescriptionAtiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways; efficaciously inhibits the proliferation of FDCP-EpoR JAK2 (V617F) (IC50=0.42 uM) and SET-2 cells (IC50= 0.53 uM); blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells (MM.1S, U266, and RPMI8226 MM cell lines IC50=0.5-1.25 uM), significantly inhibits production of IL-6 and inflammation in rat arthritis and autoimmune animal models.Brain Cancer Phase 2 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsSKF 106615 | Azaspirane
-
PathwayAngiogenesis
-
TargetJAK
-
RecptorJAK
-
Research AreaCancer
-
IndicationBrain Cancer
Chemical Information
-
CAS Number130065-61-1
-
Formula Weight409.524
-
Molecular FormulaC22H46Cl2N2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCCC(CC1)(CCC)CCC21CCN(CCCN(CC)CC)C2.[H]Cl.[H]Cl
-
Chemical Name3-(8,8-dipropyl-2-azaspiro[4.5]decan-2-yl)-N,N-diethylpropan-1-amine dihydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Quintás-Cardama A, et al. Invest New Drugs. 2011 Oct;29(5):818-26.
2. Neri P, et al. Leukemia. 2007 Dec;21(12):2519-26.
3. Hamasaki M, et al. Blood. 2005 Jun 1;105(11):4470-6.
4. Choudhari SR, et al. Mol Cancer Ther. 2007 Jan;6(1):112-21.
molnova catalog
related products
-
AZD-1480
A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
-
WHI-P97 HCl 211555-0...
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.?WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays.?WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.
-
BD750
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively).
